|
KMID : 0363320180390061168
|
|
Journal of Korean Oriental Internal Medicine
2018 Volume.39 No. 6 p.1168 ~ p.1180
|
|
|
The Effect of Red Ginseng on Sarcopenic Rat
|
|
Seo Yoon-Jeong
Ryu Jae-Hwan
|
|
|
Abstract
|
|
|
Objective: As the number of sarcopenic patients worldwide is increasing, the need for the treatment of sarcopenia is increasing. Ginseng has been reported to be a major herbal supplement. We tested whether red ginseng would be effective for sarcopenia using red ginseng preparation which can be easily obtained locally in Korea.
Methods: 30 rats were randomly divided into three groups: the control group (n=10) (Group C), the group with Dexamethasone -induced sarcopenia (n=10) (Group D), and the group to which red ginseng was administered group after induced sarcopenia with Dexamethasone (n=10) (Group DH). Dexamethasone was intraperitoneally administered to group D and group DH for 7 days to make sarcopenic model. After that, the red ginseng tablets prepared by Korea Ginseng Corporation were diluted in distilled water and administered orally to the DH group for 2 weeks. Body weight and grip strength were measured 8 times during the experiment. At the end of the experiment, blood was collected by cardiac puncture. In addition, the tibialis muscle was extracted, a myofibril cross section was measured by immunohistochemical staining and MyHC (myosin heavy chain) was quantified by Western blotting.
Results: The ratio of the area on myofibril cross-section showed significant differences after administration of the red ginseng tablet.
Conclusions: Red ginseng has a significant effect on the recovery of myofibril cross-section on sarcopenia. This experiment will be helpful for future clinical studies on drug effects in sarcopennia.
|
|
|
KEYWORD
|
|
|
sarcopenia, dexamethasone, red ginseng, grip strength, myosin heavy chain transition
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|